513 Zinc dyshomeostasis in patients with bullous pemphigoid and BP180-deficient mice

Background: The skin is the third most zinc-abundant organ in human body. Zinc deficiency has been linked with poor wound healing, acrodermatitis enteropathica, and alopecia. Bullous pemphigoid(BP) mainly caused by anti-basement membrane zone autoantibodies against BP180 or BP230. However, relationship between BP zinc status still unknown. Objectives: We sought to study serum levels patients gene expression profiles of homeostasis BP180-deficient control mice. Materials & Methods: A single-center retrospective from January 2010 September 2022 was conducted. transcriptome mice expressing NC16A-truncated wild-type controls were analyzed(GSE112235). Results: There 92 patients, including 48 males 44 females, who had available levels. mean age 77.9 years (range 52-96 years). level 57.8 μg/dl(range 28-98 μg/dl, normal 70-100μg/dl). prevalence 82.6%. In comparison, average 440 elderly(mean age: 78.4 years) long-term care residents 70.2 μg/dl. no significant difference age, sex, eosinophils counts patients. Comparing mice, 267 zinc-associated genes down-regulated(|fold change| ≥ 1.5 p < 0.05), only five up-regulated. Reactome pathway analysis these down-regulated genes, top transporters. Fragile a common feature improved after supply. Conclusions: more than 80%. routine survey supplement are important for